The US drones targeted a location 20 km from Wana, one of the main towns in South Waziristan late last night.
A drone fired two missiles at the spot and two more missiles were fired after a short interval, local residents were quoted as saying by BBC Urdu.
The local residents said Kashmiri was among the nine militants killed in the drone strike.
Kashmiri, 47, is considered one of the most feared operational commanders of the network that Osama bin Laden founded and has been blamed for a string of high-profile attacks on western targets, as well as in India and Pakistan.
The United States has put out a $5 million reward — the maximum for any most-wanted target — for any information that might help locate him.
He has been blamed for multiple attacks in Pakistan, including the recent May 22 siege on a naval air base in Karachi.
Counter-terrorism officials believe he was the main coordinator of a terror plot targeting Britain, France, Germany and the United States, which was apparently in the early stages when detected by intelligence agencies in 2010.
Two intelligence officials in Wana, the main town of South Waziristan, also confirmed that those killed on Friday were all Kashmiri’s fighters.